PhysOrg.com - 1.25.10
Researchers in Manchester have successfully carried out the first rewire of genetic switches, creating what could be a vital tool for the development of new drugs and even future gene therapies.
A team of scientists from the School of Chemistry and the Manchester Interdisciplinary Biocentre (MIB) at The University of Manchester have found a way of hijacking so-called 'riboswitches' and directing gene activity.
Working within cells of bacteria, chemical biologist Professor Jason Micklefield and his team have rewired these genetic switches so they are no longer activated by small naturally occurring molecules found in cells - but through the addition of a synthetic molecule.
The work builds on the recent discovery that these naturally occurring molecules can turn genes on and off by triggering riboswitches found within a large molecule called 'messenger RNA'.
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